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Published on: 2007-11-07
Released on: 2007-11-07
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The understanding of the molecular mechanisms underlying the ageing process is essential to improve quality of life and ‘health span’ in the growing populations of the elderly. Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes experimental evidence and clinical data indicating that telomere dysfunction influences human ageing, diseases and cancer. In addition, the book describes our current knowledge on checkpoints that limit cellular lifespan (senescence) and survival (apoptosis, crisis) in response to telomere dysfunction. A special focus of the book is on adult stem cells. There is emerging evidence that adult stem cell ageing impairs organismal fitness and survival and contributes to cancer formation (cancer stem cells). The book summarizes basic mechanisms of adult stem cell ageing. Moreover, the authors describe evidence that telomere dysfunction impairs stem cell function by inducing cell intrinsic checkpoints as well as environmental alterations. All of these subjects are of great interest for ageing researchers, physicians and students and should provide a rational basis for beginning to identify molecular targets for novel therapies that aim to improve quality of life during ageing. Scientists extend telomeres to slow cell aging KurzweilAI Ray what are your thoughts about getting this commercialised and approved by the FDA. Telomere lengthening seems to be the answer to reversing aging by many human ... Telomerase - Wikipedia Telomerase also called terminal transferase is a ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. Elizabeth Blackburn (UCSF) Part 1: The Roles of Telomeres ... ibiology.org/ibioseminars/genetics-gene-regulation/elizabeth-blackburn-part-1.html Lecture Overview Telomerase a specialized ribonucleprotein ... Protect telomeres and decelerate aging with 4 common vitamins (NaturalHealth365) Telomeres repeating sequences of DNA located at the ends of chromosomes play a key role in survival and aging. Preserving the length of telomeres ... Telomerase definition of telomerase by Medical dictionary telomerase [t-lomer-s] a DNA polymerase involved in the formation of telomeres and the maintenance of telomere sequences during replication. Telomeres: Cap It All Off with Diet NutritionFacts.org Transcript: Telomeres: Cap It All Off with Diet. What about exercise for slowing cellular aging? Stress management helps but we can't always change our station in ... Telomere - Wikipedia A telomere is a region of repetitive nucleotide sequences at each end of a chromosome which protects the end of the chromosome from deterioration or from fusion with ... Telomeres and Cancer - News Medical A ribonucleoprotein enzyme complex known as telomerase maintains telomere length in cancer cells by adding TTAGGG repeats onto the telomeric ends compensating for ... Facts About Telomeres and Telomerase - UT Southwestern To better understand telomeres and telomerase let's first review some basic principles of biology and genetics. The human body is an organism formed by adding many ... Sierra sciences on Curing Aging Developing drugs and therapies to reverse the effects of human aging by focusing on preserving the length of telomeres to keep them more resilient. Careers in Reno ...
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